Megaloblastic anaemia associated with sulphasalazine treatment.
نویسندگان
چکیده
منابع مشابه
Megaloblastic anaemia due to sulphasalazine responding to drug withdrawal alone.
A 60 year old man with ulcerative colitis since 1975 and treated with sulphasalazine, presented with severe megaloblastic anaemia caused by folate deficiency. The drug was stopped, and the anaemia recovered promptly. There was no relapse one year later.
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In 1954 Badenoch described two cases of megaloblastic anaemia which developed in epileptics while under treatment with phenytoin sodium and phenobarbitone, and subsequently I2 further cases have been recorded (Hawkins and Meynell, 1954; Chalmers and Boheimer, I954; Rhind and Varadi, I954; Webster, 1954; Berlyne, Levene and McGlashan, 1955; Ryan and Forshaw, I955; Vaishnava, I955). Six of these ...
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Nowadays scurvy is fortunately rare. Cases are still found among the inmates of common lodging houses and those living alone, where age, decrepitude, or apathy may have led to an inadequate dietary intake. Rigid dieting as in peptic ulcer' may be an unusual cause. While the blood picture may show little change in the milder cases, anaemia of variable degree occurs in most adults with scurvy. It...
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A nine years old boy presented with history of pallor and anaemia since early infancy along with neural hearing loss responding to empirical multivitamin and folic acid therapy started on basis of blood complete picture showing anaemia and megaloblastic anaemia. On investigation he was diagnosed with Thiamine Responsive Megaloblastic Anaemia, a very rare condition in our settings.
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Generalized skin pigmentation in five African women with megaloblastic anaemia in the postnatal period was associated with low serum folate levels, as distinct from vitamin B(12) deficiency. It is suggested that the occurrence of pigmentation in both folate and vitamin B(12) deficiency may reflect a common abnormality of metabolism.
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6080.190-a